The study of the processes that causes aging of all living beings is a subject that has attracted not only more recently the interest of scientists. The research has operated for decades, to this day created many different theories to explain in different ways, the aging process.
Aging by free radicals
This theory was developed in 1954 by the scientist D. Harman at the University of Nebraska.
The theory asserts that key molecules of the organism in the metabolic processes in the body damaged by free radicals. Free radicals are short-lived, aggressive, oxygen-containing compounds. The free radicals must be eliminated from the body, with the added burden which oxidative stress, which can cause cell damage. The accumulation of oxidative damage in the cell is in effect for the progressive deterioration of the cells responsible, since upfront by DNA damage. This man is older.
Age due to wear and wear
Wear and tear are responsible for the aging of living beings. According to the theory of the U.S. American's R. Pearl (1879-1940) leads the activity of the institutions to abrasion and wear on the body and its cells, in the course of life is always more noticeable. This is the way of life a positive or a negative effect on the wear and tear. The body's own repair systems that function properly in youth can, after retirement, and thus ensure the outside see wrinkles, gray hair and internally for vascular deposits.
The Hayflick theory
The Hayflick theory is named after the U.S. American L. Hayflick of the University of California. The scientists created the foundations of modern research on aging. As an employee at the Wistar Institute in Philadelphia, he discovered in 1962 together with his colleague Paul S. Moorhead that connective tissue cells called fibroblasts have only a limited life
This discovery was revolutionary at the time, because that was the earlier prevailing assumption that human fibroblasts are capable of dividing indefinitely, refuted. The researchers showed that human cells divide about 50 times during their lifetime before they died.
The hormonal theory
Young adults have until mid 20, the highest blood concentrations of hormones, are in fact using their physical and mental performance overhead. From early 30s, there is a progressive hormone decrease, and with mid-50s have testosterone decreases by about a third, more than half of DHEA and growth hormone by two thirds. The waste of many hormones leads to loss of function of many body systems. A low hormone level is regarded as the cause of many age-related diseases and aging.
The glucose theory
Anthony Cerami, members of the Picower Institute for Medical Research in Manhasset, showed the involvement of glucose to the cell aging process.
The researchers showed that glucose binds to proteins. By combining two different materials creates the Amadori product. It can form new structures, enter the irreversible compounds with other molecules called AGEs (advanced glycosylation end products). These molecules are finally formed in a position to cross-connections to other molecules, which ultimately affects the functioning of the cells.
